Embosphere Microspheres

Predictable. Targeted. Established.

Embosphere® Microspheres are among the most clinically studied and proven round embolic, providing consistent and predictable results for effective embolization.

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Embosphere Microspheres

Features & Benefits

PREDICTABLE

Embosphere Microspheres temporarily compress up to 33% for smooth microcatheter passage. Once through the microcatheter, they return to their original spherical shape and stated diameter for predictable, reliable delivery.¹

TARGETED

Embosphere Microspheres show a direct correlation between the level of arterial occlusion and the size of the particles used, allowing for consistent and reliable targeted occlusion.^2,3

ESTABLISHED

Embosphere Microspheres have been proven:

• In over 350,000 procedures⁴
• With +20 years’ clinical experience⁴
• In more than 200 clinical articles, including 136 pivotal clinical articles⁴
• A total of 6,660 cases involving Embosphere Microsphere, based on the pivotal literature⁴

NON-AGGREGATING PROPERTIES

The hydrophilic surface and spherical shape of Embosphere Microspheres prevent aggregation in the catheter lumen and vasculature.

SUPERIOR REBOUND CAPABILITY

Embosphere Microspheres’ elastic properties allow temporary compression of up to 33% to facilitate smooth microcatheter passage (A).¹ Once through the microcatheter, Embosphere Microspheres return to their original spherical shape and stated diameter (B) for predictable, targeted delivery.¹

Image shows 800um Embosphere Microspheres in a catheter on the left; and, Embosphere Microspheres within a solution; showcasing the rebound effect of the spheres

DURABLE OCCLUSION

Embosphere Microspheres are biocompatible and nonresorbable with cell adhesion properties that enable complete and durable mechanical occlusion.

Image shows 2 microscopic images of Embosphere at 6 months after occlusion (A) and at 6 years after occlusion (B)

Embosphere Microspheres at six months (A) and six years (B) after embolization of facial AVM.
Images courtesy of Dr. Alex Laurent, Hôpital Lariboisière, Paris, France

PERCENTAGE OF PATIENTS WITH COMPLETE INFARCTION RATES OF OVERALL UTERINE FIBROID TUMOR BURDEN

Image: Bar chart comparing complete infarction rates of Embosphere Microspheres (92%), to Contour SE (66.7%), Embozene (60%), and BeadBlock (45%, near-complete) With Embosphere Microspheres, 100% infarction of the entire uterine fibroid tumor burden has been reported in up to 92.3% of patients.

Complete infarction of all fibroids leads to better long-term clinical outcomes, including a higher rate of symptom control and a lower rate of additional gynecologic intervention compared with incomplete infarction of fibroid tissue.⁸

Leiomyoma infarction above 90% on contrast-enhanced MR images after UAE show significantly better symptom control and fewer reinterventions than patients with a lower infarction rate.⁹

*UFE rates are defined differently; results are from different studies and may vary in head-to-head comparison, graphics are for illustration purposes only.

REFERENCES

1. Laurent, et al. Trisacryl Gelatin Microspheres for Therapeutic Embolization, I: Development and In Vitro Evaluation. Am J Neuroradial. 1996 Mar; 17:533-540
2. Pelage JP, et al. Uterine Artery Embolization in Sheep: Comparison of Acute Effects with Polyvinyl Alcohol Particles and Calibrated Microspheres. Radiol. 2002;224:436-45
3. Verret V, et al. The Arterial Distribution of Embozene and Embosphere Microspheres in Sheep Kidney and Uterus Embolization Models. J Vasc Interv Radiol. 2011 Feb;22(2):220-8
4. Data on file